Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12)
Als2cr12 evidence at protein level. with a probable tetraspanin-like membrane structure, that is localized in photoreceptors and in the postsynaptic outer plexiform layer and that interacts with cytoskeletal proteins. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Monoclonal Antibody to Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 12 (ALS2CR12) ELISA Kit Customized Service Offer