Anaphase Promoting Complex Subunit 4 (ANAPC4)

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.

The deduced 809-amino acid APC4 protein did not appear to have a yeast homolog. Yu et al. (1998) stated that the APC is highly conserved from yeast to humans.