Angiomotin Like Protein 2 (AMOTL2)

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. AMOTL2 encoded by this gene is related to angiomotin and is a member of the motins protein family.

In the presence of angiostatin, endothelial cells that overexpress angiomotin exhibit a significant reduction in migration toward growth factors as well as an inability to form tubules in vitro. These observations are consistent with the localization of angiomotin in the leading edge of migrating cells. Angiostatin, therefore, disrupts the normal migratory function of Angiomotin.