Ankyrin Repeat And FYVE Domain Containing Protein 1 (ANKFY1)

ANKFY1 encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.The deduced 1,184-amino acid protein has an apparent molecular mass of 130 kD. Ankhzn contains an N-terminal coiled-coil domain, a BTB/POZ domain, 17 ankyrin repeats, and a C-terminal zinc finger motif. The ankyrin repeats are separated into a group of 4 repeats in the N-terminal half and a group of 13 repeats in the C-terminal half.