Annexin A8 (ANXA8)

Human annexin VIII was originally identified by Hauptmann et al. (1989) from a 2-kb cDNA transcript containing an open reading frame that encoded a 327-amino acid protein termed vascular anticoagulant beta. It is a minor annexin in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia.

Affected human promyelocytes contain a nonrandom chromosomal translocation breakpoint involving chromosomes 15 and 17 and creating 2 hybrid mRNA fusion products and chimeric proteins. These involve the retinoic acid receptor-alpha gene (RARA) on chromosome 17q12 and the promyelocytic leukemia gene (PML; 102578) on chromosome 15q22.