Anterior Pharynx Defective 1A (APH1A)
CGI-78; PSF; Presenilin-stabilization factor; Gamma-secretase subunit APH-1A
APH-1 (anterior pharynx-defective 1) is a protein gene product originally identified in the Notch signaling pathway in Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin. APH-1 homologs in other organisms, including humans, have since been identified as components of the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2. The gamma-secretase complex is a multimeric protease responsible for the intramembrane proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). Gamma-secretase cleavage of APP is one of two proteolytic steps required to generate the peptide known as amyloid beta, whose misfolded form is implicated in the causation of Alzheimer's disease.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to Anterior Pharynx Defective 1A (APH1A) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Anterior Pharynx Defective 1A (APH1A) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Anterior Pharynx Defective 1A (APH1A) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Anterior Pharynx Defective 1A (APH1A) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Anterior Pharynx Defective 1A (APH1A) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Anterior Pharynx Defective 1A (APH1A) ELISA Kit Customized Service Offer