Apical Early Endosomal Glycoprotein (AEGP)

Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells. The apical endosomal compartment is thought to be involved in the sorting and selective transport of receptors and ligands across polarized epithelia. The deduced amino acid sequence predicts a protein of 1216 amino acids with a molecular mass of 133,769 Da. The deduced amino acid sequence together with amino-terminal amino acid sequencing indicate that there is a cleaved 21-amino acid signal sequence at the NH2-terminal portion of the molecule. There is a single hydrophobic region near the carboxyl terminus that has the characteristics of a membrane-spanning domain and a 36-amino acid cytoplasmic tail. The cytoplasmic tail contains a possible internalization motif and several consensus motifs for serine/threonine kinases.