Apolipoprotein L6 (APOL6)

ApoL6 is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles.

The deduced 343-amino acid protein has a calculated molecular mass of 38.1 kD. The authors noted that the APOL proteins share significant sequence identity within the predicted amphipathic alpha helix. Semiquantitative RT-PCR revealed ubiquitous expression of APOL6, with highest levels in uterus, fetal brain, and spinal cord.The COMT gene on chromosome 22q11 is 15.2 Mb from the APOL6 gene, which is located at the telomeric end of the APOL gene cluster. The APOL1 gene is at the telomeric end of the cluster.