Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1)
Identification of new anti-apoptotic genes is important for understanding the molecular mechanisms underlying apoptosis and tumorigenesis. The present study identified a novel anti-apoptotic gene named AREL1, which encodes a HECT (homologous to E6-AP carboxyl terminus) family E3 ubiquitin ligase. AREL1 interacted with and ubiquitinated IAP antagonists such as SMAC, HtrA2, and ARTS. However, AREL1 was cytosolic and did not localize to nuclei or mitochondria. The interactions between AREL1 and the IAP antagonists were specific for apoptosis-stimulated cells, in which the IAP antagonists were released into the cytosol from mitochondria. AREL1-mediated ubiquitination and degradation of cytosolic forms of three IAP antagonists plays an important role in the regulation of apoptosis.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Monoclonal Antibody to Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Apoptosis Resistant E3 Ubiquitin Protein Ligase 1 (AREL1) ELISA Kit Customized Service Offer