Apoptosis Antagonizing Transcription Factor (AATF)
CHE1; DED; Rb-binding protein Che-1
Protein AATF was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.By differential display for genes downregulated by TGFB in an intestinal crypt epithelial cell line, Lindfors et al. (2000) cloned AATF.The AATF transcript contains several 4-nucleotide repeats, and the deduced 560-amino acid protein contains a leucine zipper motif, several phosphorylation sites, a nuclear localization signal, and 3 nuclear receptor LxxLL binding motifs.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA440Hu01 Recombinant Apoptosis Antagonizing Transcription Factor (AATF) In Stock
- Polyclonal antibody PAA440Hu01 Polyclonal Antibody to Apoptosis Antagonizing Transcription Factor (AATF) In Stock
- Customized Service n/a CLIA Kit for Apoptosis Antagonizing Transcription Factor (AATF) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Apoptosis Antagonizing Transcription Factor (AATF) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPA440Mu01 Recombinant Apoptosis Antagonizing Transcription Factor (AATF) In Stock
- Polyclonal antibody PAA440Mu01 Polyclonal Antibody to Apoptosis Antagonizing Transcription Factor (AATF) In Stock
- Customized Service n/a CLIA Kit for Apoptosis Antagonizing Transcription Factor (AATF) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Apoptosis Antagonizing Transcription Factor (AATF) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPA440Ra01 Recombinant Apoptosis Antagonizing Transcription Factor (AATF) In Stock
- Polyclonal antibody PAA440Ra01 Polyclonal Antibody to Apoptosis Antagonizing Transcription Factor (AATF) In Stock
- Customized Service n/a CLIA Kit for Apoptosis Antagonizing Transcription Factor (AATF) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Apoptosis Antagonizing Transcription Factor (AATF) ELISA Kit Customized Service Offer