Coatomer Protein Complex Subunit Delta (COPD)

Archain 1encoded by the ARCN1 gene, the coatomer protein delta-COP, probably plays a fundamental role in eukaryotic cell biology. Tunnacliffe at al. (1996)demonstrated that it is conserved across diverse eukaryotes. Very close or identical matches were seen in rat and cow; highly significant matches were seen with 2 plant species, A. thaliana (cress) and S. tuberosum (potato). A 200-kb genomic fragment from a YAC that includes MLL was used to screen a cDNA library of the R54;11 cell line which carries a translocation chromosome t(4;11)(q21; q23). The cDNA sequence predicts a 511-amino acid protein which shares similarity with predicted proteins of unknown function from rice (Oryza sativa) and Drosophila. Because of this ancient conservation the authors proposed the name archain (ARCN1).