Armadillo Repeat Containing Protein 2 (ARMC2)

Armadillo/beta-catenin (CTNNB1)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC2, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis.

Armadillo repeats are named after the β-catenin-like Armadillo protein of the fruit fly Drosophila. Each Armadillo repeat is composed of a pair of alpha helices that form a hairpin structure. β-catenin is a protein involved in linking cadherin cell adhesion proteins to the cytoskeleton. But the Armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important in transducing WNT signals during embryonic development.