Armadillo Repeat Containing Protein, X-Linked 3 (ARMCX3)

ARMCX3 encodes a member of the ALEX family of proteins which may play a role in tumor suppression. ARMCX3 contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene.Like ALEX2, the deduced 379-amino acid ALEX3 protein contains a potential N-terminal transmembrane domain and a single arm repeat. ALEX3 is identical to an alpha-fodrin SH3 domain-binding partner. EST database searching of cDNA libraries detected ESTs matching ALEX3 in various tissues, but not in liver, thymus, or leukocytes.