Ataxin 3 (ATXN3)

AT3; ATX3; JOS; MJD; MJD1; SCA3; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein; Olivopontocerebellar Ataxia 3; Autosomal dominant,Ataxin 3
Ataxin 3 (ATXN3)
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
ATXN3 has deubiquitinase activity and appears to be a component of the ubiquitin proteasome system. It may also have roles in transcriptional regulation and neuroprotection.
Organism species: Homo sapiens (Human)
  • Protein RPD250Hu01Recombinant Ataxin 3 (ATXN3)Customize
  • AntibodyPAD250Hu01Polyclonal Antibody to Ataxin 3 (ATXN3)Customize
  • AntibodyMAD250Hu21Monoclonal Antibody to Ataxin 3 (ATXN3)Customize
  • Assay KitSED250HuELISA Kit for Ataxin 3 (ATXN3)Customize
  • Assay KitSCD250HuCLIA Kit for Ataxin 3 (ATXN3)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPD250Mu01Recombinant Ataxin 3 (ATXN3)Customize
  • AntibodyPAD250Mu01Polyclonal Antibody to Ataxin 3 (ATXN3)Customize
  • AntibodyMAD250Mu21Monoclonal Antibody to Ataxin 3 (ATXN3)Customize
  • Assay KitSED250MuELISA Kit for Ataxin 3 (ATXN3)Customize
  • Assay KitSCD250MuCLIA Kit for Ataxin 3 (ATXN3)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPD250Ra01Recombinant Ataxin 3 (ATXN3)Customize
  • AntibodyPAD250Ra01Polyclonal Antibody to Ataxin 3 (ATXN3)Customize
  • AntibodyMAD250Ra21Monoclonal Antibody to Ataxin 3 (ATXN3)Customize
  • Assay KitSED250RaELISA Kit for Ataxin 3 (ATXN3)Customize
  • Assay KitSCD250RaCLIA Kit for Ataxin 3 (ATXN3)Customize
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