Ataxin 7 Like Protein 3 (ATXN7L3)

ATXN7L3 belongs to the SGF11 family. Component of some SAGA transcription coactivator-HAT complex, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitinylation. Interacts directly with ENY2 and USP22.

A putative ataxin-7 yeast orthologue (SGF73) has been identified recently as a new component of the SAGA (Spt/Ada/Gcn5 acetylase) multisubunit complex, a coactivator required for transcription of a subset of RNA polymerase II-dependent genes. ataxin-7 is the human orthologue of the yeast SAGA SGF73 subunit and is a bona fide subunit of the human TFTC-like transcriptional complexes. Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.