Autophagy Related Protein 2B (ATG2B)
C14orf103
Mounting evidence indicates that alterations of autophagy processes are directly involved in the development of many human diseases, including cancers. Autophagy-related gene (ATG) products are main players in the autophagy process. In humans there are 16 known ATG genes, of which four (ATG2B, ATG5, ATG9B and ATG12) have mononucleotide repeats with seven or more nucleotides. Frameshift mutations of genes with mononucleotide repeats are features of cancers with microsatellite instability (MSI). It is not known whether ATG genes with mononucleotide repeats are altered by frameshift mutations in gastric and colorectal carcinomas with MSI. Frameshift mutations in ATG genes with mononucleotide repeats are common in gastric and colorectal carcinomas with MSI-H, and suggest that these mutations may contribute to cancer development by deregulating the autophagy process.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to Autophagy Related Protein 2B (ATG2B) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Autophagy Related Protein 2B (ATG2B) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Autophagy Related Protein 2B (ATG2B) ELISA Kit Customized Service Offer