B9 Protein Domain 2 (B9D2)

Town et al. (2008) cloned mouse B9d2, which they called stumpy. The deduced 175-amino acid protein contains an N-terminal B9/C2 calcium/lipid-binding region. RT-PCR of mouse tissues detected widespread stumpy expression, with highest levels in thymus and skeletal muscle. In situ hybridization showed stumpy expression throughout early postnatal mouse brain.

Town et al. (2008) found that mouse stumpy colocalized with ciliary basal bodies, physically interacted with gamma-tubulin, and was present along ciliary axonemes in transfected HeLa cells and canine kidney cells, suggesting that stumpy plays a role in ciliary axoneme extension.