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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Bcl2 Associated Athanogene 3 (BAG3)
BIS; CAIR1; BAG Family Molecular Chaperone Regulator 3
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPC335Hu01 Recombinant Bcl2 Associated Athanogene 3 (BAG3) Customize
Antibodies MAC335Hu22 Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Customize
PAC335Hu01 Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Customize
Assay Kits SEC335Hu ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) In Stock
SCC335Hu CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPC335Mu01 Recombinant Bcl2 Associated Athanogene 3 (BAG3) Customize
Antibodies PAC335Mu01 Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Customize
MAC335Mu21 Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Customize
Assay Kits SEC335Mu ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) Customize
SCC335Mu CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPC335Ra01 Recombinant Bcl2 Associated Athanogene 3 (BAG3) Customize
Antibodies PAC335Ra01 Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Customize
MAC335Ra21 Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) Customize
Assay Kits SEC335Ra ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) Customize
SCC335Ra CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) Customize