BRCA1 Associated RING Domain Protein 1 (BARD1)
BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant BRCA1 Associated RING Domain Protein 1 (BARD1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to BRCA1 Associated RING Domain Protein 1 (BARD1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to BRCA1 Associated RING Domain Protein 1 (BARD1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for BRCA1 Associated RING Domain Protein 1 (BARD1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for BRCA1 Associated RING Domain Protein 1 (BARD1) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant BRCA1 Associated RING Domain Protein 1 (BARD1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to BRCA1 Associated RING Domain Protein 1 (BARD1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to BRCA1 Associated RING Domain Protein 1 (BARD1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for BRCA1 Associated RING Domain Protein 1 (BARD1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for BRCA1 Associated RING Domain Protein 1 (BARD1) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant BRCA1 Associated RING Domain Protein 1 (BARD1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to BRCA1 Associated RING Domain Protein 1 (BARD1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to BRCA1 Associated RING Domain Protein 1 (BARD1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for BRCA1 Associated RING Domain Protein 1 (BARD1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for BRCA1 Associated RING Domain Protein 1 (BARD1) ELISA Kit Customized Service Offer