BTB/POZ Domain Containing Protein 9 (BTBD9)

By sequencing clones obtained from a size-fractionated adult amygdala cDNA library, Nagase et al (2001) cloned BTBD9, which they designated KIAA1880. The BTBD9 transcript has an MIR repetitive element in its 5-prime UTR. The deduced 642-amino acid protein contains a BTB/POZ domain. RT-PCR detected high expression of BTBD9 in kidney and moderate expression in all other adult and fetal tissues and specific brain regions examined.

By genomic sequence analysis, Nagase et al (2001) mapped the BTBD9 gene to chromosome 6.For a discussion of a possible association between variation in the BTBD9 gene and restless legs syndrome, see RLS6 .