BTB/POZ Domain Containing Protein 2 (BTBD2)

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain, both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.

BTBD2 colocalized with BTBD1 in punctate or elongated cytoplasmic bodies in all cell types tested. None of the BTBD1/BTBD2 immunostaining colocalized with common organelle or cytoskeleton marker proteins.the last C-terminal 50 residues of BTBD2 interacted with TOP1; the BTB domain was not required for this interaction. Recombinant BTBD2 slightly inhibited the supercoil relaxation activity of TOP1 and produced a slight inhibition of TOP1 cleavage activity.