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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Bloom Syndrome Protein (BLM)
BS; RECQ2; RECQL2; RECQL3; RecQ Helicase-Like
BLM protein is located in the nucleus of normal human cells in the nuclear domain 10 (ND10) or promyelocytic leukemia nuclear bodies. These structures are punctate deposits of proteins disrupted upon viral infection and in certain human malignancies.
BLM was found primarily in ND10 except during S phase, when it colocalized with the WRN gene product, in the nucleolus. BLM colocalized with a select subset of telomeres in normal cells and with large telomeric clusters seen in simian virus 40-transformed normal fibroblasts. During S phase, Bloom syndrome cells expel micronuclei containing sites of DNA synthesis. The BLM protein is likely to be part of a DNA surveillance mechanism operating during S phase.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPK201Hu01 Recombinant Bloom Syndrome Protein (BLM) Customize
Antibodies PAK201Hu01 Polyclonal Antibody to Bloom Syndrome Protein (BLM) Customize
MAK201Hu21 Monoclonal Antibody to Bloom Syndrome Protein (BLM) Customize
Assay Kits SEK201Hu ELISA Kit for Bloom Syndrome Protein (BLM) Customize
SCK201Hu CLIA Kit for Bloom Syndrome Protein (BLM) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPK201Mu01 Recombinant Bloom Syndrome Protein (BLM) Customize
Antibodies PAK201Mu01 Polyclonal Antibody to Bloom Syndrome Protein (BLM) Customize
MAK201Mu21 Monoclonal Antibody to Bloom Syndrome Protein (BLM) Customize
Assay Kits SEK201Mu ELISA Kit for Bloom Syndrome Protein (BLM) Customize
SCK201Mu CLIA Kit for Bloom Syndrome Protein (BLM) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPK201Ra01 Recombinant Bloom Syndrome Protein (BLM) Customize
Antibodies PAK201Ra01 Polyclonal Antibody to Bloom Syndrome Protein (BLM) Customize
MAK201Ra21 Monoclonal Antibody to Bloom Syndrome Protein (BLM) Customize
Assay Kits SEK201Ra ELISA Kit for Bloom Syndrome Protein (BLM) Customize
SCK201Ra CLIA Kit for Bloom Syndrome Protein (BLM) Customize