Bloom Syndrome Protein (BLM)

BS; RECQ2; RECQL2; RECQL3; RecQ Helicase-Like; DNA helicase, RecQ-like type 2
Bloom Syndrome Protein (BLM)
BLM protein is located in the nucleus of normal human cells in the nuclear domain 10 (ND10) or promyelocytic leukemia nuclear bodies. These structures are punctate deposits of proteins disrupted upon viral infection and in certain human malignancies.
BLM was found primarily in ND10 except during S phase, when it colocalized with the WRN gene product, in the nucleolus. BLM colocalized with a select subset of telomeres in normal cells and with large telomeric clusters seen in simian virus 40-transformed normal fibroblasts. During S phase, Bloom syndrome cells expel micronuclei containing sites of DNA synthesis. The BLM protein is likely to be part of a DNA surveillance mechanism operating during S phase.
Organism species: Homo sapiens (Human)
  • Protein RPK201Hu01Recombinant Bloom Syndrome Protein (BLM)Customize
  • AntibodyPAK201Hu01Polyclonal Antibody to Bloom Syndrome Protein (BLM)Customize
  • AntibodyMAK201Hu21Monoclonal Antibody to Bloom Syndrome Protein (BLM)Customize
  • Assay KitSEK201HuELISA Kit for Bloom Syndrome Protein (BLM)Customize
  • Assay KitSCK201HuCLIA Kit for Bloom Syndrome Protein (BLM)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPK201Mu01Recombinant Bloom Syndrome Protein (BLM)Customize
  • AntibodyPAK201Mu01Polyclonal Antibody to Bloom Syndrome Protein (BLM)Customize
  • AntibodyMAK201Mu21Monoclonal Antibody to Bloom Syndrome Protein (BLM)Customize
  • Assay KitSEK201MuELISA Kit for Bloom Syndrome Protein (BLM)Customize
  • Assay KitSCK201MuCLIA Kit for Bloom Syndrome Protein (BLM)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPK201Ra01Recombinant Bloom Syndrome Protein (BLM)Customize
  • AntibodyPAK201Ra01Polyclonal Antibody to Bloom Syndrome Protein (BLM)Customize
  • AntibodyMAK201Ra21Monoclonal Antibody to Bloom Syndrome Protein (BLM)Customize
  • Assay KitSEK201RaELISA Kit for Bloom Syndrome Protein (BLM)Customize
  • Assay KitSCK201RaCLIA Kit for Bloom Syndrome Protein (BLM)Customize
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