Bone Marrow Stromal Cell Antigen 2 (BST2)
CD317; Tetherin; HM1.24 antigen
Tetherin is a type 2 integral membrane protein, with the N-terminus in the cytoplasm, one membrane spanning domain, and a C-terminus modified by the addition of a glycosyl-phosphatidylinositol (gpi) anchor. When the virion buds from the surface of the cell, one of the tetherin membrane domains is in the new viral membrane, the other remains in the plasma membrane, tethering the virion to the cell. It is antagonized by the viral protein Vpu which is thought to work by targetting tetherin for degredation via the beta-TrCP2 dependent pathway.
Tetherin exists as a dimer on the surface of cells, and prevention of dimerisation by mutating the cystine residues, prevents tetherin from inhibiting virus release, although it is still detectable in the cell.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB777Hu01 Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2) In Stock
- Eukaryotic protein EPB777Hu61 Eukaryotic Bone Marrow Stromal Cell Antigen 2 (BST2) In Stock
- Polyclonal antibody PAB777Hu01 Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) In Stock
- Monoclonal antibody MAB777Hu22 Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) In Stock
- Sandwich ELISA SEB777Hu ELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) In Stock
Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) ELISA Kit Customized Service Offer