C-Myc Binding Protein 2 (MYCBP2)

The deduced 4,641-amino acid protein has a calculated molecular mass of 510 kD. PAM contains an N-terminal leucine zipper; 2 RCC1 homology domains (RHD1 and RHD2) separated by a basic region; a cell division sequence motif; 2 direct repeats of 91 amino acids (PAM repeats); a second leucine zipper; a serine-rich region that contains a domain homologous to histone-binding proteins, such as Xenopus N1/N2 (NASP); a putative nuclear localization signal; a potential ring zinc finger domain; and 2 putative C2H2-type zinc finger motifs.

Northern blot analysis detected highest expression of a 15-kb PAM transcript in brain and thymus. Expression was moderate in skeletal muscle, pancreas, and ovary and weak in all other tissues examined.