C-Type Lectin Domain Family 5, Member A (CLEC5A)

CLEC5Aencodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation.

The predicted Clecsf5 protein is a type II transmembrane protein consisting of a short, 2-amino acid intracellular region, a transmembrane domain containing a positively charged amino acid that enables it to pair with Dap12, and an extracellular domain containing characteristic structural motifs of the C-type lectin superfamily.