C1q And Tumor Necrosis Factor Related Protein 5 (C1QTNF5)

The CTRP5 protein is a member of the C1q / tumor necrosis factor superfamily, which shows diverse functions including cell adhesion and as components of the basement membrane. C1QTNF5 is mutant in late-onset retinal degeneration.

CTRP5 gene consists of 3 exons that generate a 1.8-kb transcript. It is contained within the 3-prime untranslated region of exon 13 of the MFRP gene. CTRP5 is present in the same orientation as MFRP, and both genes are expressed as a bicistronic transcript.CTRP5 and MFRP interact directly in a yeast 2-hybrid system. Other observations suggested that CTRP5 is secreted by the RPE and is a constituent of the Bruch membrane.