CDC Like Kinase 2 (CLK2)

CLK2 encodes a member of the CLK family of dual specificity protein kinases. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.The longer CLK2 cDNA encodes a predicted 499-amino acid protein that has a nonconserved N-terminal domain, a highly conserved C-terminal kinase domain, and multiple potential phosphorylation sites. This CLK2 isoform has 61% and 56% sequence identity with the CLK3 and CLK1 proteins, respectively. The shorter cDNA contains an internal deletion corresponding to an 88-bp exon, resulting in a predicted 139-amino acid protein that lacks the kinase domain. Southern blot analysis of human genomic DNA suggested that CLK2 is a single-copy gene.