CDGSH Iron Sulfur Domain Protein 3 (CISD3)

CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation.

By database analysis using CISD1 as query, Wiley et al., 2007 identified CISD3, which they called MINER2. The deduced 126-amino acid protein contains 2 C-terminal CDGSH domains. Immunofluorescence localized CISD3 to the mitochondria. They noted that purified recombinant CISD3 was strikingly red in color. Wiley et al., 2007 showed that the CDGSH domain of CISD1 harbors a redox-sensitive 2Fe-2S cluster and suggested that the CDGSH domains of CISD3 likewise bind 2Fe-2S and have similar biophysical properties.