COBW Domain Containing Protein 2 (CBWD2)

Cobalamin synthase W domain-containing protein 2

COBW Domain Containing Protein 2 (CBWD2)
By examining genes arising from intra- and interchromosomal duplications involving the ancestral chromosome 2 fusion site, followed by PCR of a fetal brain cDNA library, Fan et al. (2002) cloned CBWD2. They also identified the paralogs CBWD1 and CBWD3.
No 2 of the 3 CBWD paralogs are identical, but they all encode a deduced 395-amino acid protein containing a cobalamin synthetase W domain.Fan et al. (2002) also identified a CBWD1 splice variant lacking exons 9 and 10.
Fan et al. (2002) determined that the CBWD2 gene contains 15 coding exons and spans 59 kb.By genomic sequence analysis, Fan et al. (2002) mapped the CBWD2 gene to chromosome 2q13-q14.1.

Organism species: Homo sapiens (Human)