COBW Domain Containing Protein 5 (CBWD5)

Dopamine Responsive Protein; Cobalamin Synthase W Domain Containing Protein 5

COBW Domain Containing Protein 5 (CBWD5)
Expression of human dopamine responsive gene-1 (DRG-1) is up-regulated in response to treatment of dopamine in the rat astrocytes. However, its functions are not clear up to now. In the presented studies, DRG-1 was identified to be a conserved gene in the vertebrate and expressed abundantly in human testis, brain and skeletal muscle. DRG-1 was shown to interact with human p75NTR-associated cell death executor (NADE) in vivo and in vitro, and the interaction occurred in cytoplasm. The regions required for the interaction were subsequently mapped to the N-terminal of DRG-1 and the C-terminal of NADE. Furthermore, MTT assay showed that stable expression of DRG-1 in 293 cells could promote cell proliferation, and this promotion was suppressed by overexpression of NADE. DRG-1 may contribute to the dopamine-induced cell growth, which is negatively regulated by NADE.

Organism species: Homo sapiens (Human)