CUE Domain Containing Protein 1 (CUEDC1)

CUEDC1, Contains 1 CUE domain. The CUE domain is structurally related to the ubiquitin-binding UBA domain and is comprised of a three-helix bundle. The CUE domain has also been reported to exist as a domain-swapped dimer that makes additional contacts with ubiquitin, and consequently, binds ubiquitin with higher affinity. The CUE domain was first identified as a ubiquitin-binding motif from a yeast two-hybrid screen that could interact with monoubiquitin. The CUE domain is moderately conserved consisting of 40 amino acids and is structurally related to the ubiquitin-binding UBA domain.The CUE domain is found in proteins with diverse functions including degradation of misfolded proteins in the endoplasmic reticulum and protein sorting.