CUGBP Elav Like Family, Member 6 (CELF6)

CELF6 has 3 RRMs, with a 268-amino acid divergent domain separating RRM2 and RRM3. It also has numerous potential phosphorylation sites, a potential nuclear localization signal at the C terminus, and an alanine-rich region within the divergent domain.Northern blot analysis detected 7.5- and 4.0-kb transcripts that were abundantly expressed in kidney and brain, respectively. Both variants were detected at low levels in several other tissues. CELF6 expression in adult kidney, brain, and testis, with low expression in most other tissues. CELF6 was detected in fetal brain, but only low expression was detected in fetal kidney. Western blot analysis showed that full-length CELF6, isoform-2, and isoform-4 were expressed in transfected quail fibroblasts, but isoform-3 was not detected, apparently due to protein instability.