Calcineurin (CaN)
PPP3CA; PPP3-CA; CCN1; CNA1; CALN; CALNA1; PP2B; PP2-B; Protein Phosphatase 3(formerly 2B),Catalytic Subunit,Alpha Isoformprotein Phosphatase 2B; Calcineurin A Alpha
Calcineurin is responsible for activating the transcription of interleukin 2 (IL-2), that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus (Elidel) and tacrolimus (FK506) - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. Calcineurin is linked to receptors for two brain chemicals, NMDA and dopamine. A MIT experiment with genetically altered mice who could not produce calcineurin showed similar symptoms as in humans with schizophrenia: impairment in working memory, attention deficits, aberrant social behavior and several other abnormalities characteristic of schizophrenia.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB323Hu01 Recombinant Calcineurin (CaN) In Stock
- Polyclonal antibody PAB323Hu01 Polyclonal Antibody to Calcineurin (CaN) In Stock
- Monoclonal antibody MAB323Hu22 Monoclonal Antibody to Calcineurin (CaN) In Stock
- Sandwich ELISA SEB323Hu ELISA Kit for Calcineurin (CaN) In Stock
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Calcineurin (CaN) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Calcineurin (CaN) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Calcineurin (CaN) Polyclonal Antibody Customized Service Offer
- Sandwich ELISA SEB323Mu ELISA Kit for Calcineurin (CaN) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPB323Ra01 Recombinant Calcineurin (CaN) In Stock
- Polyclonal antibody PAB323Ra01 Polyclonal Antibody to Calcineurin (CaN) In Stock
- Monoclonal antibody MAB323Ra21 Monoclonal Antibody to Calcineurin (CaN) In Stock
- Sandwich ELISA SEB323Ra ELISA Kit for Calcineurin (CaN) In Stock