Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2 (CAMK2N2)

CAMKIIN shares 98% amino acid identity with rat Camkiin-beta and 65% identity with rat Camkiin-alpha. Northern blot analysis detected robust expression of a 5.2-kb transcript in kidney and liver, with moderate expression in heart, skeletal muscle, and placenta, low expression in small intestine, and no expression in colon, thymus, spleen, lung, peripheral blood leukocytes (PBLs), or brain.

A 1.65-kb CAMKIIN transcript was expressed in brain at a high level. Expression was also detected in cancer cell lines of diverse tissue origin. RT-PCR detected strong expression in stimulated DCs derived from PBLs and lower expression in unstimulated mature and immature DCs. No expression was detected in monocytes, T cells, or B cells.