Calcium Channel, Voltage Dependent, Gamma Subunit 2 (CACNg2)

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures.

CACNg2is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family.The deduced 315-amino acid CACNG2 transmembrane protein is 98% identical to CACNG3 and mouse Cacng2, but only 18% identical to CACNG1.