Calcium Modulating Ligand (CAMLG)
CAML; Calcium Signal-Modulating Cyclophilin Ligand; Calcium-Signal Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.
Calcium signal-modulating cyclophilin ligand functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC356Hu01 Recombinant Calcium Modulating Ligand (CAMLG) In Stock
- Polyclonal antibody PAC356Hu01 Polyclonal Antibody to Calcium Modulating Ligand (CAMLG) In Stock
- Customized Service n/a CLIA Kit for Calcium Modulating Ligand (CAMLG) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Calcium Modulating Ligand (CAMLG) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPC356Mu01 Recombinant Calcium Modulating Ligand (CAMLG) In Stock
- Polyclonal antibody PAC356Mu01 Polyclonal Antibody to Calcium Modulating Ligand (CAMLG) In Stock
- Customized Service n/a CLIA Kit for Calcium Modulating Ligand (CAMLG) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Calcium Modulating Ligand (CAMLG) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPC356Ra01 Recombinant Calcium Modulating Ligand (CAMLG) In Stock
- Polyclonal antibody PAC356Ra01 Polyclonal Antibody to Calcium Modulating Ligand (CAMLG) In Stock
- Customized Service n/a CLIA Kit for Calcium Modulating Ligand (CAMLG) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Calcium Modulating Ligand (CAMLG) ELISA Kit Customized Service Offer