Calmodulin 2 (CALM2)

CALM2 contains 6 exons and spans more than 16 kb. Within the 5-prime flanking region, CALM2 contains a TATA-like sequence, a far upstream CCAAT box, several AP1-, AP2-, and CRE-binding sites, and a repeated AGGGA motif that is found in other CALM genes.

although the CALM1, CALM2, and CALM3 proteins are identical, at the nucleotide level they share only about 80% identity within their coding regions, and they contain no significant homology within their noncoding regions.Northern blot analysis revealed a major 1.4-kb transcript in all tissues tested, with highest expression in brain. High levels of expression were also found in heart, placenta, lung, liver, skeletal muscle, and kidney, with lowest levels found in pancreas.