Calmodulin Binding Transcription Activator 2 (CAMTA2)

CAMTA2 is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.

Chromatin immunoprecipitation assays of primary neonatal rat cardiomyocytes showed that Camta2 associated with the Nkx2.5 response element in the Anf promoter. In transfected COS cells, coexpression of Nkx2.5 with Camta2 enhanced association of Camta2 with the Anf promoter. Camta2 showed nuclear and cytoplasmic localization in transfected COS cells.