Calsequestrin (CASQ)

PDIB1; CASQ1; Calsequestrin 1,Fast-Twitch,Skeletal Muscle; Calmitine; Calsequestrin, skeletal muscle isoform

Calsequestrin (CASQ)
Calsequestrin, an acid glycoprotein located in the luminal space of the terminal cisternae of the sarcoplasmic reticulum, binds calcium ion and is believed to function as a storage protein for calcium. Comparison of the complete amino acid sequences of rabbit fast-twitch muscle calsequestrin and dog cardiac muscle calsequestrin, as derived from sequence cDNAs, indicate that these isoforms are clearly the products of different genes. The rabbit fast-twitch muscle calsequestrin has, in the mature protein, 367 amino acid residues. It is synthesized with a 28-residue N-terminal signal sequence that is cleaved off during synthesis. Calmitine is a mitochondrial calcium-binding protein specific for fast-twitch muscle fibers. It is absent in patients with Duchenne and Becker types of muscular dystrophy and in dystrophic dy/dy mice.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)