Cancer Associated Nucleoprotein (CANP)

FAM111B; Family With Sequence Similarity 111 Member B

Cancer Associated Nucleoprotein (CANP)
CANP mRNA was expressed fetal liver and in various adult and fetal tissues, but the mRNA levels were very low in adult livers. CANP is developmentally regulated during liver development and downregulated during the liver development and maturation, as well as during the differentiation of HepG2 cells. Southern blot analysis did not show amplificatin of CANP gene at 11q12. CANP mRNA was overexpressed in 160 (74%) of 216 unifocal primary HCCs. CANP overexpression did not correlate with tumor grade, tumor stage and early tumor recurrence of HCC after hepatecomy. CANP mRNA overexpression is an early event during the growth of HCC. The 293T CANP stable cell showed more rapid cell growth than the controls and exhibited more colonies on 0.35% soft agar. 293T CANP stable transfectants developed tumor in NOD/SCID mice.

Organism species: Homo sapiens (Human)