TBC1 Domain Family, Member 10C (TBC1D10C)

Carabin is an endogenous inhibitor of calcineurin that also inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein activity. Carabin inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Expression of carabin is upregulated on T cell receptor (TCR) signaling in a manner that is sensitive to inhibitors of calcineurin, indicating that carabin constitutes part of a negative regulatory loop for the intracellular TCR signaling pathway.Carabin was so named on the basis of its ability to interact with both calcineurin and Ras. Human carabin consists of 446 amino acid residues and is 88% identical in sequence to the mouse ortholog. Carabin contains a putative Ras/Rab GAP domain at its amino terminus and a carboxy-terminal domain that mediates its interaction with calcineurin.