Carbohydrate Sulfotransferase 5 (CHST5)

The carbohydrates of glycoconjugates are highly diverse structures with variation in monosaccharide composition, glycosidic linkage positions, and branching of chains. Further diversity is added by the covalent addition of sulfate moieties to particular hydroxyl groups and amino groups of saccharides. They can have a profound effect on the physiochemical properties of the glycoconjugates, at least in part through the addition of negative charge.

CHST5 belongs to the GST family of sulfotransferases, which also includes CHST1, CHST2, CHST3, and LSST. These enzymes are 6-O-sulfotransferases, which add sulfate to C6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc).