Carbohydrate Sulfotransferase 8 (CHST8)

Sulfate groups in carbohydrates confer highly specific functions on glycoproteins, glycolipids, and proteoglycans and are critical for cell-cell interaction, signal transduction, and embryonic development. Sulfotransferases, such as CHST8, carry out sulfation of carbohydrates.

The deduced 424-amino acid protein has a calculated molecular mass of 48.8 kD. It has an N-terminal transmembrane domain, followed by putative 5-prime-phosphosulfonate- and 3-prime-phosphate-binding sites and 3 additional regions conserved in other sulfotransferases. GalNAc4ST1 has 4 potential N-glycosylation sites.GalNAc4ST1 transferred sulfate to C4 of GalNAc in the context of GalNAc-beta-1,4-GlcNAc-beta-1-R in both N- and O-glycans; products were monosulfated.