Carbonyl Reductase 2 (CBR2)
AP27; LCR; Adipocyte protein P27; Adipocyte protein P27; Lung carbonyl reductase; NADPH-dependent carbonyl reductase 2
CBR2, Belongs to the short-chain dehydrogenases/reductases (SDR) family. Lung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in adipose tissue > testis = heart > kidney = spleen > brain = liver.May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
Carbonyl reductases (CREDs) are enzymes useful for enantiomeric resolutions, chemo- and regioselective reductions/oxidations, and synthesis of chiral alcohols from ketones, ketoacids, and ketoesters. They also catalyse the reduction of a number of aldehydes. The CRED catalysed reduction of the carbonyl moiety requires cofactor (NADH or NADPH) regeneration and is carried out with either isopropyl alcohol or with glucose dehydrogenase.
Organism species: Mus musculus (Mouse)
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