CTD Small Phosphatase 2 (CTDSP2)

By sequencing genes within a region of chromosome 12 amplified in sarcomas and brain tumors, Su et al. (1997) cloned CTDSP2, which they designated OS4. The deduced 283-amino acid protein has a calculated molecular mass of 31.8 kD. Northern blot analysis detected expression in all tissues examined, with highest expression in pancreas and lowest expression in brain, lung, and liver.

Su et al. (1997) found that expression of CTDSP2 mRNA was enhanced in several cancer cell lines with amplification of the CTDSP2 and CDK4 genes. CTDSP2 was also coamplified with CDK4 in 5 of 5 primary sarcomas. Su et al. (1997) hypothesized that CTDSP2 may contribute to the development of a subset of sarcomas.