Cardiac Microvascular Endothelial Cells (CMEC)

Vascular endothelial cells are lining in blood and vascular tissue, composed of a layer of flat cells. It can not only complete metabolism of blood and tissue fluid exchange, playing a role in the maintenance of vascular tone, regulating blood pressure and blood coagulation and anticoagulation equilibrium special function. Microvascular is composed of a single layer of endothelial cells.

Cardiac microvascular endothelial cells （CMEC）regulate vascular tone through the release and degradation of endothelium derived vasoactive substances, by regulating the activity of the enzyme to regulate the levels of vascular contraction factor and vascular expansion factor. CMEC can differentiate into muscle cells, which indicates the role of the endothelial cells in the accumulation of matrix abnormalities and the role of fibrosis in the disease.