Casein Kinase 1 Gamma 3 (CSNK1g3)

The casein kinase I (CKI) gene family encodes serine/threonine kinases that preferentially phosphorylate acidic substrates using ATP as a phosphate donor. CKI proteins are monomeric and range from 25 to 55 kD. They are ubiquitous, being found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells.

The deduced 447-amino acid CSNK1G3 protein shares 98% sequence identity with rat CKI gamma-3. The authors also isolated a cDNA whose sequence is identical to that of the aforementioned CSNK1G3 cDNA except that it contains a 24-bp insertion in the coding sequence and an 8-bp insertion in the 3-prime untranslated region. They suggested that this cDNA represents an alternatively spliced CSNK1G3 transcript, which they named CSNK1G3L.