Caspase 10 (CASP10)

ALPS2; FLICE2; MCH4; Apoptosis-Related Cysteine Peptidase; Cysteinyl Aspartate Specific Proteinases 10; FAS-associated death domain interleukin-1B-converting enzyme 2

Caspase 10 (CASP10)

CASP10,a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.

This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)