Caspase Recruitment Domain Family, Member 10 (CARD10)

CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB) through BCL10. The deduced 1,032-amino acid protein contains an N-terminal CARD domain that shares 58% identity with that of CARD11, a central coiled-coil domain, and a C-terminal tripartite structure comprised of a PDZ domain, an SH3 domain, and a GUK domain. Northern blot analysis revealed expression of a 4.4-kb transcript in a variety of adult tissues, including heart, kidney, and liver. CARD10 was also expressed in fetal lung, liver, and kidney, and in multiple cancer cell lines.