Cbp/p300 Interacting Transactivator, With Glu/Asp Rich Carboxy Terminal Domain 2 (CITED2)

CITED2 inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene. The predicted 213-amino acid human MRG1 protein contains 3 histidine clusters and shares 2 conserved domains with MSG1: the 14-amino acid CR1 (conserved region 1) and the acidic 49-amino acid CR2. The CR2 domain includes 12 aspartic acid and glutamic acid residues that are strictly conserved among the human and mouse MRG1 and MSG1 proteins. Northern blot analysis detected MRG1 expression in normal human epidermal melanocytes and in melanoma cells; mouse Mrg1 transcripts were found in all adult mouse tissues examined except muscle.